indazole synthesis Secrets
Substitution at R3 by using a halogen or alkoxy group (74f–74i) resulted in a slight increase in mobile potency with the halide analogs (74g–h) demonstrating optimum the potency from the group. Even further optimization resulted in the discovery of 74i–j, with 74k as the most Lively compound while in the series (pIC50 = six.77) with very good